Focus on… Praluent®

  • Lynda Steyn Amayeza Information Services
Keywords: Praluent®, cholesterol, premature atherosclerotic cardiovascular disease


Cholesterol plays a pivotal role in the functioning of healthy cells.1 Being mostly lipophilic, cholesterol is transported in the blood inside lipophilic particles, e.g. high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL). Hypercholesterolaemia refers to elevated low-density lipoprotein cholesterol (LDL-C) levels, and increases the risk for premature atherosclerotic cardiovascular disease (ASCVD).1  Low-density lipoprotein receptors (LDL-R) on the surface of hepatocytes, are the primary receptors involved in clearing circulating LDL-C.2

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